The primary use of allopurinol is to treat hyperuricemia (excess uric acid in blood plasma) and its complications. Allopurinol does not alleviate acute attacks of gout, but is useful in chronic gout to prevent future attacks. Similarly, allopurinol commonly is used as prophylaxis with chemotherapeutic treatments, which can rapidly produce severe hyperuricemia. Other established indications for allopurinol therapy include ischaemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis) and protozoal infections (Leishmaniasis). Also used to prevent tumor lysis with certain types of cancer. Because allopurinol is not a uricosuric, it can be used in patients who have poor kidney function.
There appears to be no specific contra-indication to the use of allopurinol, other than known intolerance. However, a reduction of dosage should be considered in the presence of severe renal or hepatic disorders.
Dosage Forms:
Zynol 100mg Tablet
Each tablet contains Allopurinol BP—–100mg
Zynol 300mg Tablet
Each tablet contains Allopurinol BP—–300mg