Neoplastic Diseases: Methotrexate is indicated in the treatment of gestational horiocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of menigeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma). and lung cancer, particularly squamous cell, small cell types and advanced stage non-Hodgkin’s lymphomas. Methotrexate in high doses followed by leucovorin rescue in combination with other emotherapeutic agents is effective in prolonging relapse-free surviaval in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor. Psoriasis: Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy, but only when the diagnosis has been established, as by a biopsy and/or after dermatologic consultation. It is important to ensure that a psoriasis elfiare is not due to an undiagnosed concomitant disease affecting immune responses. Rheumatoid Arthritis including Poiya rticula r-Course Juvenile. Rheumatoid Arthritis: Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthriteis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis, who have had an insufficient therapeutic response to, or are intolerant of, an adequate trial of first-line therapy including full dose nonsteroidal anti-inflammatory agents (NSAIDs).
Dosage Forms:
Pharmatrexate Injection:
Glass Vial containing methotrexate 50 mg as methotrexate sodium in sterile powder form.
Pharmatrexate- 2.5 Tablets :
Each tablet contains methotrexate B.P 2.5 mg .
Pharmatrexate – 10 Tablets:
Each tablet contains methotrexate B.P 10 mg.