Effective on all forms of malaria.
Treatment of choice in malaria cases resistant to other therapies like chloroquine, amodiaquine, Pyrimethamine alone.
Can be given with other antimalarial drugs particularly quinine.
Malaria is one of the most serious protozoal infections in man caused by all the four forms of plasmodium. P. falciparum causes falciparum malaria, which is the most serious form of malaria and can be rapidly fatal in non-immune patients, if not treated promptly. P. vivax causes vivax malaria which is widespread but rarely fatal, although symptoms during the primary attack can be severe. P. malariae causes quartan malaria which is generally mild but can cause fatal nephrosis and P. ovale causes ovale malaria, which is the least common type of malaria and produces symptoms similar to P. vivax. Chloroquine has been widely used for long periods, but partly or wholly resistant strains of P. falciparum have emerged over wide areas. Unfortunately resistance to the two alternative prophylactics, proguanil and Pyrimethamine has made them ineffective in these areas. The use of combination regimen including Pyrimethamine and Sulfadoxine initially proved highly effective in areas of choloroquine resistance, but increasing concern about serious side effects has limited their usefulness. (G.C. Cook.,J. Infect 1986, 13.1.)
Dosage Forms:
Each tablet contains Sulfadoxine 500mg + Pyrimethamine 25mg.
Each 15ml Suspension contains Sulfadoxine 500mg + Pyrimethamine 25mg.